Epitalon, also known as Epithalon or AEDG (Ala-Glu-Asp-Gly), is a synthetic tetrapeptide derived from polypeptides found in pineal gland extract. It has gained attention for its potential to activate telomerase, an enzyme critical for maintaining telomere length, thereby promoting cellular rejuvenation and potentially extending lifespan in various organisms (Araj et al., 2025; Bi et al., 2022).

Recommended Dosage and Usage

Dosage: The recommended dosage for Epitalon typically ranges from 5 to 10 mg administered per day for optimal results Gatta et al., 2025)Sadowska‐Bartosz & Bartosz, 2014). Some protocols suggest using Epitalon in a cyclic manner, for periods of 10 to 20 days, followed by breaks to sustain its efficacy and minimize potential desensitization Vanhee et al., 2014; .

Administration Method: Epitalon is primarily administered through subcutaneous injections, which enhance absorption and bioavailability. Though oral administration has been investigated, its efficacy is considerably lower compared to injections due to stability and absorption issues (Araj et al., 2025; Gatta et al., 2025).

Clinical Applications: Studies indicate that Epitalon exhibits antioxidant properties and rejuvenates cellular function by reducing oxidative stress — a critical factor in aging. Research suggests it may enhance telomere length and longevity in laboratory animals, implicating applications in age-related conditions, cancer therapy, and eye diseases, such as retinitis pigmentosa (Raymond, 2024; Vanhee et al., 2014; Avolio et al., 2022). Additionally, its neuroprotective effects have been suggested through improvements in brain function tied to telomerase activation (Сибаров et al., 2007).

Conclusion

Epitalon emerges as a noteworthy peptide with potential geroprotective properties, influencing longevity through mechanisms that include telomere elongation and antioxidant activity. Adhering to recommended dosages and consistent monitoring is crucial to optimize therapeutic outcomes. The combined effects of Epitalon on biological aging and cellular health prompt further research to fully understand its clinical potential in enhancing longevity and quality of life.